Estimates are calculated by looking at sections of DNA from your genome and comparing those pieces to DNA from known genetic populations. When your DNA aligns closely to identified DNA from a specific region, we can confirm your ancestry and provide you with a percentage breakdown of your ancestry per region.
Sema4’s algorithm pulls from numerous sources in order to calculate your regional genetic ancestry. Variants from your DNA are compared to a reference set containing the DNA of thousands of individuals from known populations. The reference set we use is made up of multiple publicly available datasets, as well as a private dataset from Gencove, a third-party partner whose gene-sequencing technology we used to calculate your regional genetic ancestry.