Sema4 Natalis was carefully designed by a team of clinical and molecular geneticists, pediatricians, and scientists to provide accurate and useful results. There are three primary ways that a genetic test can be evaluated:
- Analytic validity, or how accurately a test can detect a certain genetic change (or variant). All DNA samples for Sema4 Natalis are analyzed in our CLIA-certified lab using advanced DNA sequencing technology that is >95% accurate
- Clinical validity, or how well a genetic test can predict a certain disease. Sema4 Natalis only screens for genetic changes that are highly penetrant. This means that if someone is born with genetic change(s) screened for by this test, there is a high probability (>80%) that they will develop symptoms of the associated disease
- Clinical utility, or whether a genetic test provides useful information that can help improve treatment choices or other healthcare decisions. Sema4 Natalis only screens for conditions that may be treated* with medication, dietary modification, or other therapies.
You can learn more about how to evaluate the validity of a genetic test through Genetics Home Reference, a website from the U.S. National Library of Medicine.
*Always consult with your child’s pediatrician before taking any medical action or starting treatment based on results of screening with Sema4 Natalis.